How ZMapp antibodies bind to Ebola virus

ZMapp, a mixture of three antibodies against Ebola virus, became a household name after it was used to treat two Americans who were infected while working in Liberia. The structure of these antibodies bound to the Ebola virus glycoprotein suggest how they inhibit infection and ways to improve ZMapp. The three monoclonal antibodies that comprise ZMapp (called c13C6, c2G4, and c4G7) were …

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