DHF/DSS

TWiV 473: Assessing a risk and infecting you twice

2 Comments / This Week in Virology / By Vincent Racaniello

The Fellowship of the Virus discuss enhancement of dengue disease in humans: the contribution of antibody concentration and increased binding to Fc receptors. <span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”>ï»¿</span><span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”>ï»¿</span>&lt;span data-mce-type=”bookmark” style=”display: inline-block; width: 0px; overflow: hidden; line-height: 0;” class=”mce_SELRES_start”&gt;ï»¿&lt;/span&gt;&amp;lt;span data-mce-type=”bookmark” …

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Antibodies mediate severe dengue in humans

2 Comments / Basic virology, Information / By Vincent Racaniello

Severe dengue virus disease, also known as dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS), is most likely to occur in previously infected individuals experiencing a second encounter with a different serotype. A specific range of serum antibody titers has been shown to enhance viral replication in cell culture and in animal models, and now in humans.

DHF/DSS

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