Defective genomes modulate respiratory syncytial virus pathogenesis

During viral replication, defective genomes may arise that lack essential sequences. These so-called defective genomes cannot replicate unless they are in the same cell as a helper virus. Defective genomes play a role in modulating pathogenesis of respiratory syncytial virus in humans. Copy-back defective viral genomes (cbDVGs) of RSV arise when the viral RNA polymerase …

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