Dogma Does Not Belong in Science

by Gertrud U. Rey According to established scientific dogma, infection of cells with HIV-1 leads to delivery of the viral capsid into the cell cytoplasm, followed by “uncoating” of the capsid to release the single-stranded RNA genome. A viral-encoded enzyme called reverse transcriptase then catalyzes the conversion of the viral RNA into a single strand …

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A Viral Heist

HSV-1 virions capture the cellular motor protein kinesin from initially infected epithelial cells and ferry it to subsequently infected neuronal cells to deliver their genome into the nucleus of those cells.

Evolution of a bacterial protein into a virus-like, RNA binding capsid

Starting with a bacterial protein, directed evolution in the laboratory has been used to produce a virus-like capsid that binds and protects RNA. This finding has implications for the origins of viruses. One view of the evolution of life is that viruses were present even before the first cells in the form of self-replicating molecules. …

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TWiV 582: This little virus went to market

TWiV provides updates on the new coronavirus causing respiratory disease in China, the current influenza season, and the epidemic of African swine fever, including determination of the three-dimensional structure of the virus particle. Click arrow to play Download TWiV 582 (71 MB .mp3, 118 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at

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