The TWiVrific gang reveal how integration of a virophage into the nuclear genome of a marine protozoan enhances host survival after infection with a giant virus. You can find TWiV #419 at microbe.tv/twiv, or listen below. [powerpress url=”http://traffic.libsyn.com/twiv/TWiV419.mp3″] Click arrow to play Download TWiV 419 (64 MB .mp3, 105 min) Subscribe (free): iTunes, RSS, email Become a patron of TWiV!
Virophages (the name means virus eater) were first discovered to replicate only in amoeba infected with the giant mimiviruses or mamaviruses. They reduce yields of the giant viruses, and also decrease killing of the host cell. Another virophage called mavirus has been found to integrate into the genome of its host and behaves like an inducible antiviral defense system …
On episode #261 of the science show This Week in Virology, Vincent meets up with Chantal and Jean-Michel at the first International Symposium on Giant Virus Biology in Tegernsee, Germany, to discuss their work on Mimivirus, Megavirus, and Pandoravirus. You can find TWiV #261 at www.microbe.tv/twiv.