borna disease virus

TWiV 303: Borna this way

On episode #303 of the science show This Week in Virology, the TWiV team discusses transmission of Ebola virus, and inhibition of Borna disease virus replication by viral DNA in the ground squirrel genome. You can find TWiV #303 at www.microbe.tv/twiv.

Bornavirus DNA in the mammalian genome

The chromosomal DNA of several mammals has been found to contain sequences related to the nucleoprotein (N) gene of bornaviruses, enveloped viruses with a negative-strand RNA genome. I am amazed by this finding. How did bornaviral DNA get in our chromosomes, and what is it doing there? A search of the human genome sequence revealed DNA …

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