William Summers joins the TWiV team to discuss some virology history, including the ever-changing concept of ‘virus’ and the contribution of phage research to the study of animal viruses. Click arrow to play Download TWiV 573 (69 MB .mp3, 113 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Viruses that infect eukaryotic cells typically bind to a plasma membrane receptor to initiate the reproduction cycle. Attachment of bacteriophages to bacterial cells is more diverse. Some attach to bacterial outer membrane proteins, while others attach to appendages such as pili or flagella. How viruses move from the flagella to the bacterial cell surface is …
Shortly after Félix d€™Herelle discovered viruses that infect bacteria in 1917 (also found in 1915 by Twort), he recognized their therapeutic potential for treating infections. The discovery of penicillin in 1928 began the golden age of antibiotics, which pushed aside progress in treating infections with bacteriophages. With the advent of widespread antimicrobial resistance, development of …
Team TWiV reveals DNA polymerases that do not require a primer, and packaging of hepatitis delta virus by the envelope glycoproteins of diverse viruses. Click arrow to play Download TWiV 552 (70 MB .mp3, 116 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Each year I inform the students in my Columbia University virology course that all known DNA polymerases – viral or cellular – require a primer to initiate DNA synthesis (it€™s even stated in our textbook, Principles of Virology). This statement is no longer true, as shown by the discovery of two different DNA polymerases that …
The Scholars of the Podcast reveal ribosomal proteins encoded in viral genomes, and a protein cell receptor for bat influenza viruses. Click arrow to play Download TWiV 537 (63 MB .mp3, 104 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
