Viruses and the respiratory tract
Now that we have a rudimentary understanding of influenza virus replication, we can begin to consider how the virus causes disease – a field of study called viral pathogenesis. The…
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TWiV 40: Tamiflu in the water
…for this episode: Reston ebolavirus in Philippine swine Historical perspective on H1N1 virus Salk’s 1947 article on flu vaccine failure Persistent legacy of 1918 H1N1 virus Tamiflu resistant H1N1 virus…
TWiV 51: ALVAC-HIV and AIDSVAX B/E
…difficult (pdf), and arguments for the trial Chile immunizes salmon (USGS article on the virus, pdf) Blueberry virus strikes Michigan research center (information on the disease and the virus) Rotavirus…
A protein platform for priming
…Nile viruses), influenza virus (genome RNA synthesis is primer independent), reovirus, and bacteriophage phi6. Perhaps all viral RNA-dependent RNA polymerases are dependent on such priming platforms to initiate RNA synthesis….
Defective genomes modulate respiratory syncytial virus pathogenesis
During viral replication, defective genomes may arise that lack essential sequences. These so-called defective genomes cannot replicate unless they are in the same cell as a helper virus. Defective genomes…
Architecture of a bullet-shaped virus
Since electron micrographs first revealed the bullet-shaped morphology of vesicular stomatitis virus (a virus related to rabies virus), understanding the architecture has been elusive. It was known that the RNA…