Influenza neuraminidase and H5N1 pathogenicity
…virus with an N1 from an 1996 H5N1 virus with an intact stalk, as well as viruses with NAs harboring different deletions of various lengths. The findings in mice paralleled…
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Coxsackie NY and the virus named after it
…Coxsackieviruses were isolated that cause a variety of clinical syndromes. Today at least 30 serotypes of Coxsackieviruses are classified in the enterovirus genus of the Picornaviridae. The viruses are classified…
ACIP recommendations on monovalent H1N1 vaccine
…the reduced susceptibility of older individuals to infection with the 2009 pandemic virus is likely a consequence of their previous exposure to an antigenically cross-reactive strain of the virus. Another…
An antiviral compound that blocks SARS-CoV-2 transmission in ferrets
…are introduced into the viral genome, causing lethal mutagenesis and inhibition of infectivity. NHC has been previously shown to have broad-spectrum anti-RNA virus activity and blocks transmission of influenza virus…
The complement system
…Lysis – Polymerization of specific activated complement components on a foreign cell or enveloped virus leads to the formation of pores. The lipid bilayer of the cell or virus is…
A Nobel for autophagy, and the importance of fundamental research
…cellular adaptive immune system, further enhancing clearance. Autophagy may also benefit virus replication. For example, non-lytic cell to cell spread of poliovirus depends on release of virus particles from autophagosomes,…