Poliovirus vaccine, SV40, and human cancer
Deep sequencing – which identified a viral contaminant of the rotavirus vaccine Rotarix – could have revealed the presence of simian virus 40 (SV40) in the poliovirus vaccine, had the…
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A plant virus that switched to vertebrates
…infected plant. The virus adapted to vertebrates, and the circovirus family was established. After the host switch from plants to vertebrates, recombination took place between the circovirus and a vertebrate…
XMRV in human respiratory tract
An important question about the retrovirus XMRV, which has been implicated in prostate cancer and chronic fatigue syndrome, is where the virus replicates in humans. Such information would provide clues…
Headless HA: Universal influenza vaccine?
A serious shortcoming of current influenza virus vaccines is the need to reformulate them every year or two as the virus undergoes antigenic drift. Many virologists have been captivated by…
XMRV, prostate cancer, and chronic fatigue syndrome
…xenotropic and polytropic murine leukemia viruses and hence was named xenotropic murine leukemia virus-related virus, or XMRV. Five lines of evidence indicate that XMRV is not a laboratory contaminant: XMRV…
Receptor for new coronavirus-EMC identified
…molecules on the cell surface. Identification of cell receptors for viruses is an important objective because their study may lead to information about how the virus enters the cell, how…