Virology
TWiV 901: COVID-19 clinical update #115 with Dr. Daniel Griffin
By Vincent Racaniello | | This Week in Virology
In COVID-19 clinical update #115, Dr. Griffin reviews cross-variant immunity without vaccination, EUA for boosters in 5-11 year olds, B.1.1.529 attack rate, scent dogs, Omicron and pets, Paxlovid, Veklury, Fluvoxamine, antigen positivity after isolation, inflammasome activation and severe disease, and GI persistence and fecal shedding.
TWiV 900: Burning down the mouse
By Vincent Racaniello | | This Week in Virology
TWiV celebrates 900 episodes, Vincent gives the Richard R. Ernst lecture, and we discuss why inflammasome activation in infected macrophages drives severe COVID-19. Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Kathy Spindler, and Brianne Barker Click arrow to playDownload TWiV 900 (65 MB .mp3, 108 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Fighting Viruses with Viruses
By Gertrud U. Rey | | Basic virology, Gertrud Rey
by Gertrud U. Rey Errors during viral replication can give rise to shortened and/or rearranged genomic sequences known as “defective viral genomes” (DVGs). Because DVGs often lack critical elements needed for replication and formation of new viral particles, virions containing DVGs can only complete a replication cycle if they co-infect a cell together with respective …
TWiV 896: Memory B cells, the way we were
By Vincent Racaniello | | This Week in Virology
TWiV explains a study of how climate change is predicted to increase cross-species viral transmission risk, and increased memory B cell potency and breadth after a SARS-CoV-2 mRNA vaccine boost. Hosts: Vincent Racaniello, Dickson Despommier, and Amy Rosenfeld Click arrow to playDownload TWiV 896 (65 MB .mp3, 108 min)Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at …
TWiV 895: COVID-19 clinical update #112 with Dr. Daniel Griffin
By Vincent Racaniello | | This Week in Virology
In COVID-19 clinical update #112, Dr. Griffin reviews seroprevalence of infection-induced antibodies, Moderna filing for vaccine authorization in young children, public health impact of vaccines in US, FDA approval of first treatment for young children, phase 2 data for Sabizabulin, and post infection inflammation.
TWiV 894: Dinner with the TMPRSS family
By Vincent Racaniello | | This Week in Virology
TWiV explains what is known about cases of acute, severe hepatitis of unknown origin in children, and discovery of an inhibitor of TMPRSS2 protease that blocks SARS-CoV-2 infection.
David Tuller
Trial By Error: Some Things I’ve Read Recently…
By David Tuller, DrPH *This is a crowdfunding month at UC Berkeley. If you’d like to support my work, the link is here. ********** Julie Rehmeyer explores a friend’s death in New York Times’ Modern Love column It is hard to imagine having to cope with the aftermath of someone dying of suicide in your home. …
Trial By Error: Are Claims of “Recovery” from Psycho-Behavioral Interventions a Form of Bait-and-Switch ?
By David Tuller, DrPH *This is a crowdfunding month at UC Berkeley. If you’d like to support my work, the link is here. In a medical context, what does “recovery” mean? A pretty standard understanding is this one offered by The Free Dictionary: “a return to a normal or healthy condition.” If experts suggest a …
Trial By Error: Professor Chalder Downgrades Definition of “Recovery”
By David Tuller, DrPH President Trump’s words and actions are routinely mind-boggling but never surprising, given past experience. The same is true of papers co-authored by Trudie Chalder, King’s College London’s mathematically and factually challenged professor of cognitive behavior therapy. In a recent article, she holds true to form. In “Recovery from chronic fatigue syndrome: …
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Trial By Error: Claims Built on Fraudulent Trials Should Be Ignored
By David Tuller, DrPH When researchers cite fraudulent studies in support of their claims, it is best not to take anything they write at face value. That is certainly the case with a recent paper titled “Persistent physical symptoms not explained by structural abnormalities or disease processes: a primary care approach to promote recovery,” published …
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Trial By Error: Is Professor Crawley Retired from Bristol, or Isn’t She?
By David Tuller, DrPH Professor Esther Crawley, the methodologically and ethically challenged pediatrician and former grant queen at the University of Bristol, retired from medical practice and, apparently, from academia at some point in the recent past. So why does her name still appear on websites as if she were an active participant in research …
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Trial By Error: Norway Disability Case Exposes Flaws in Draft Guideline for “Long-Term Fatigue–including ME/CFS”
By David Tuller, DrPH A recent disability case in Norway provides a good example of why the draft of a new guideline for “long-term fatigue—including ME/CFS” is so problematic. As I reported last week, the draft guideline, produced by the Norwegian Directorate of Health*, generally favors the biopsychosocial approach. The guideline offers few specifics about …