A huge host contribution to virus mutation rates
…always been thought that the sources of such mutations are the enzymes that copy viral RNA genomes: they make random errors which they cannot correct. Now it appears that a…
Search Results for: Trial by Error
A virus with a green thumb
…error! Why did it take so long to figure out the role of poly(A) at the 5’-end of vaccinia virus mRNAs? The right technology was not available – the key…
“Paxlovid Rebound” Is Just COVID Rebound
…reducing the margin of error and for obtaining results that are both accurate and clinically useful. Second, the participants tested themselves, which could have introduced unknown errors such as whether…
An inborn error of innate immunity leading to severe rhinovirus infections
…As a consequence it will be possible to determine what mutations correlate with unusual disease susceptibility. This information might be used to correct such inborn errors. The child in this…
There is one, and only one strain of SARS-CoV-2
…It is the noise produced by error-prone RNA synthesis by the virus. Viruses with D614S are simply virus isolates. They are not strains of SARS-CoV-2. Because of the founder effect,…
The future of SARS-CoV-2
…through humans over the years, its genome will slowly accumulate mutations as a consequence of error-prone replication. Some of these mutations will be lethal and cause viral replication to cease….