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Pandoravirus, bigger and unlike anything seen before

29 Comments / Basic virology, Information / By Vincent Racaniello

The discovery of the giant Mimivirus and Megavirus amazed virologists (and also many others). Their virions (750 nanometers) and DNA genomes (1,259,000 base pairs) were the biggest ever discovered, shattering the notions that viruses could not be seen with a light microscope, and that viral genomes were smaller than bacterial genomes. Now two even bigger viruses have been discovered, …

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Poliovirus silently (and not so silently) spreads

6 Comments / Basic virology, Information / By Vincent Racaniello

Poliovirus has been found in sewage in Israel. The virus detected is not vaccine-derived poliovirus; it is wild-type 1 poliovirus, the strain that occurs naturally in the wild and which the World Health Organization is trying very hard to eradicate from the planet. As part of the global effort to eradicate poliovirus, environmental samples from …

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David Bhella on electron-cryomicroscopy

1 Comment / Basic virology, Information / By Vincent Racaniello

I interviewed structural virologist David Bhella in Manchester, England at the spring meeting of the Society for General Microbiology. MWV Episode 74 – David Bhella – Electron-cryomicroscopy from microbeworld on Vimeo.

Dual virus-receptor duel

7 Comments / Basic virology, Information / By Vincent Racaniello

Viruses are obligate intracellular parasites: they must enter a cell to reproduce. To gain access to the cell interior, a virus must first bind to one or more specific receptor molecules on the cell surface. Cell receptors for viruses do not exist only to serve viruses: they also have cellular functions. An example is the transferrin …

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The largest viral genome from a human

8 Comments / Basic virology, Information / By Vincent Racaniello

The biggest known viruses are Mimivirus (750 nanometer capsid, 1.2 million base pair DNA) and Megavirus (680 nanometer capsid, 1.3 million base pair DNA). These giant viruses have all been isolated from environmental samples, and many infect amoebae. A new Mimivirus has now been isolated from a human patient with pneumonia. To search for giant …

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Notifiable diseases in the US for 2011

7 Comments / Information / By Vincent Racaniello

The US Centers for Disease Control and Prevention has released a summary of notifiable diseases in the US for the year 2011. These statistics are collected and compiled from reports sent by state health departments and territories to the National Notifiable Diseases Surveillance System (NNDSS). According to the CDC, a notifiable disease is one for which …

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