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Enterovirus D68 and childhood paralysis

The Centers for Disease Control and Prevention thinks that viruses play a role in the childhood paralysis called acute flaccid myelitis (AFM). The finding of antibodies to enterovirus D68 (EV-D68) in the cerebrospinal fluid of patients with AFM strengthens the link between infection with this virus and AFM. Acute flaccid myelitis (AFM), which mainly occurs …

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Avoiding error catastrophe with recombination

RNA viruses exist close to their error threshold, the point beyond which additional mutations cause loss of infectivity. It has been suggested that RNA recombination prevents viruses from exceeding the error threshold – a situation called error catastrophe – but there has been little experimental support for this hypothesis. An analysis of poliovirus RNA synthesis …

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Zika virus infection causes neurological deficits without microcephaly

Children who are exposed to Zika virus in utero may develop structural defects of the cranium such as microcephaly. Now we understand that even children born to Zika virus infected mothers may develop neurodevelopmental and neurosensory deficiencies in the second year of life – in the absence of microcephaly. During the 2015-16 Zika virus epidemic …

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