Each year I inform the students in my Columbia University virology course that all known DNA polymerases – viral or cellular – require a primer to initiate DNA synthesis (it€™s even stated in our textbook, Principles of Virology). This statement is no longer true, as shown by the discovery of two different DNA polymerases that …
At Retroviruses 2019 in Cold Spring Harbor, Vincent speaks with virologist Bryan Cullen about his work and his career, together with former associates Ann Skalka, Paul Bieniasz, and Michael Malim. Click arrow to play Download TWiV 551 (37 MB .mp3, 60 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV!
TWiV explains the use of a neuronal cell line to study herpes simplex virus latency and reactivation, and a strategy for creating vaccines that induce antibodies against specific epitopes. Click arrow to play Download TWiV 550 (64 MB .mp3, 105 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
A method for making vaccines that induce antibodies against a specific epitope could be used to produce a universal influenza vaccine that would not have to be changed every year.
Kartik Chandran and Rohit Jangra join the TWiV team to present their identification of protocadherin-1 as a cell receptor for New World hantaviruses. Click arrow to play Download TWiV 549 (62 MB .mp3, 103 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Infection with yellow fever virus caused the death of a patient 25 years after receiving a kidney transplant, illustrating the difficulties associated with some medical vaccine exemptions. The patient had received a kidney transplant at the age of 58 in February 1993. Nearly 25 years later he was admitted to hospital with two days of …
