Author name: Vincent Racaniello

I'm Professor of Microbiology and Immunology at Columbia University in New York. I run a research lab where we study poliovirus, rhinovirus, and other RNA viruses. I also love teaching about viruses - check out virology.ws, microbe.tv, or iTunes University for some of my offerings. I want to be Earth's virology professor.

A single amino acid change switches avian influenza H5N1 and H7N9 viruses to human receptors

Two back-to-back papers were published last week that provide a detailed analysis of what it would take for avian influenza H5N1 and H7N9 viruses to switch to human receptors. Influenza virus initiates infection by attaching to the cell surface, a process mediated by binding of the viral hemagglutinin protein (HA) to sialic acid. This sugar …

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Treating hepatitis C by blocking a cellular microRNA

Miravirsen is a drug that binds to and blocks the function of a cellular microRNA called miR-122 that is required for the replication of hepatitis C virus (HCV). Treatment of chimpanzees chronically infected with HCV with this drug leads to suppression of viral replication. The results of a phase 2b human clinical trial in HCV …

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