The Sabin infectious, attenuated poliovirus vaccines are known to cause vaccine-associated paralysis in a small number of recipients. In contrast, the Salk inactivated vaccine does not cause poliomyelitis. Why are the Sabin vaccines still used globally? The answer to this question requires a brief visit to the history of poliovirus vaccines. The inactivated poliovirus vaccine (IPV) developed by …
ASM Live will be broadcast from ICAAC/ICC 2015 in San Diego, CA, where host Michael Schmidt, PhD, Professor and Vice Chairman of Microbiology and Immunology at the Medical University of South Carolina, and co-host of This Week in Microbiology, will interview researchers about their work. Streaming will take place at the San Diego Convention Center, Room 29B, and meeting registrants …
On episode #353 of the science show This Week in Virology, the TWiVniacs discuss twenty-eight years of poliovirus shedding by an immunodeficient patient, and packaging of the innate cytoplasmic signaling molecule cyclic GMP-AMP in virus particles. You can find TWiV #353 at www.microbe.tv/twiv.
An immunodeficient individual has been excreting poliovirus in his stool for 28 years. Such chronic excreters pose a threat to the poliovirus eradication program. Since its inception in 1988 by the World Health Organization, the poliovirus eradication program has relied on the use of the infectious, attenuated vaccine strains produced by Albert Sabin. These viruses …
When I became Peter Palese’s first Ph.D. student in 1976, his laboratory at Mt. Sinai School of Medicine in New York City was in dire need of shelves. The laboratory benches (pictured) had no room for storing the many bottles of reagents that I was beginning to generate. When I told Peter that his laboratory needed shelves, …
On episode #352 of the science show This Week in Virology, Vincent meets up with Michele Banks in Washington, DC to discuss her career as a creator of science-themed art. You can find TWiV #352 at www.microbe.tv/twiv.
