May 2014

Should variola virus, the agent of smallpox, be destroyed?

Later this month (May 2014) the World Health Assembly will decide whether to destroy the remaining stocks of variola virus – the agent of smallpox – or to allow continued research on the virus at WHO-approved laboratories. After the eradication of smallpox in 1980, the World Health Organization called for destruction of known remaining stocks …

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Virology question of the week: What matters more, multiplicity of infection or virus concentration?

This week’s question comes from a graduate student studying virology, who writes: My professor recently said that really, the MOI doesn’t matter in a culture, it is the concentration of viral particles in the media that matters. Ie: if you have 10 million cells or one cell, but you are infecting the plate with 5mL …

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Unusual mortality pattern of 1918 influenza A virus

The 1918 influenza pandemic was particularly lethal, not only for the very young and the very old (as observed for typical influenza), but unexpectedly also for young adults, 20 to 40 years of age (pictured). It has been suggested that the increased lethality in young adults occurred because they lacked protective immunity that would be conferred …

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